О проекте

The objective of the present study is to compare the levels of the following parameters in diabetic patients with normal subjects. 1. Fasting blood sugar 2. Creatinine 3. Urea 4. Uric acid 5. Urinary Proteins DISCUSSION The inspiration for this study is to know the progression towards complications like (Nephropathy, Neuropathy, retinopathy) by analyzing bio-chemical parameters such as NPN substances by estimating the levels of NPN substances especially creatinine. We can asses the severity of renal involvement and anticipate the prognosis. The results of the present are discussed under 2 groups. 1. Control patients 2. Diabetic patients In the present study fasting blood sugar levels are estimated by method GOD – PAP methodology. The normal level of fasting blood sugar is 110 mg/dl. Total fasting blood sugar levels are significantly increased in Diabetic patient the levels being 221 ± 16.36 as compared to the control subjects in whom blood sugar levels are 78.4 ± 1.7. The serum creatinine levels are estimated by Jaffe’s method. The normal serum level of creatinine is 0.7 – 1.4 mg/dl. The normal serum creatinine levels are significantly increased in diabetic patients the levels being 5.1 ± 0.1 as compared to the control subjects in whom serum creatinine levels are 0.86 ± 0.06. The normal serum Urea levels are estimated by Berthelot method. Normal serum urea levels are 10 – 50 mg/dl. The normal serum urea levels are significantly increased in diabetic patients the levels being 110 ± 5.72 as compared control subjects in whom serum urea levels are 32 ± 1.6. The total serum uric acid levels are estimated. Normal serum uric acid levels 3.4 – 7 mg/dl. The normal serum uric acid levels are significantly increased in diabetic patients. The levels being 9.08 ± 0.8 as compared to the control subjects in whom serum uric acid levels are 4.26 ± 0.16. The clinical test for protein producing visible cloudyness (or) solid coagulum by heat is used. Trace amounts of protein are found in urinary samples and the amount of protein found in the urine proportional to renal damage. CONCLUSION Based on the above findings the following conclusions are drawn.  Fasting blood sugar levels are raised in the diabetic patients when compared to the controls.  Serum creatinine levels are raised in diabetic patients when compared to controls.  Urea levels are also increased in diabetic patients.  Uric acid levels are also increased in diabetic patients.  Increase in protein excretion indicates the severity of renal dysfunction.  From the present study we conclude that increase in serum creatinine and protein excretion in diabetic patients serves as a guide line for the clinition in assessing the renal function.

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