О проекте

Synthesis of ribosomes is a sophisticated and tightly controlled process in all living cells. Transcription of ribosomal RNA (rRNA) by RNA polymerase I can account for more than 60% of the total transcription in a growing cell. The molecular mechanisms that control the synthesis of rRNA are the focus of our research group. The research in Dr. Schneider's lab addresses three general questions: (1) How is transcription initiation by RNA polymerase I regulated? (2) What cellular factors affect the efficiency of RNA polymerase I transcription elongation? (3) How do changes in transcription elongation efficiency affect rRNA processing and ribosome assembly? To address these questions we perform a variety of biochemical and genetic experiments using the model eukaryote Saccharomyces cerevisiae. The yeast system enables us to do advanced genetic analyses and detailed biochemical experiments to fully address the questions posed above.

P Control of Gene Expression: molecular mechanisms that regulate RNA polymerase I transcription initiation and elongation.

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