«Саратовский научно-медицинский журнал» » Архив номеров » Volume 6, issue 3 » Публикация

Аннотация For the purpose of diagnostic and treatment improvement it is necessary to investigate relationship between different pathogenetic mechanisms in essential hypertension. The aim of our study was the comparative analysis of the parameters of cardiac remodeling and neurohumoral mechanisms of heart rate variability (HRV) in patients with essential arterial hypertension. 100 patients with essential arterial hypertension were included in the study. All patients went through heart rate variability parameters and left ventricle characteristics evaluation. Time and frequency domains were decreased in patients with arterial hypertension. Excess sympathetic activation takes place, parasympathetic system is depressed and it shows pathogenetic basis of disadaptation. Left ventricle hypertrophy is associated with progressive decrease of HRV and its circadian fluctuations. Concentric left ventricle hypertrophy is characterized by the most significant decrease in time and frequency domains of HRV. 1/3 of hypertensive patients with normal left ventricle geometry have diastolic dysfunction and also some decrease in time and frequency domains. In conclusion, we found that cardiac remodeling in patients with essential hypertension seems to be related to the severity of impairment of cardiac autonomic control