The objective of the present study was to evaluate
hypolipidemic effect of methanolic extract of Celastrus paniculatus in experimentally induced hypercholesterolemic rats. Hypercholesterolemia was induced by feeding the animals with high fat diet. Oral administration of methanolic
seed extract (50%) of Celastrus paniculatus at the optimized dose of 65 mg/kg body weight, substantially reduced the plasma total cholesterol, triglycerides and LDL cholesterol
in comparison with induced hypercholesterolemic animal
group and the results were comparable with the standard
hypocholesterolemic drug and almost similar to the control
group. Atherogenic index and liver weight of treated animals
also showed significant decrease compared to the
hypercholesterolemic animals. It substantially increased the
HDL cholesterol level as compared to control group. A
significant increase in the activities of lipoprotein lipase and
plasma LCAT enhanced hepatic bile acid synthesis and
thereby, increased degradation of cholesterol to neutral
sterols. Furthermore, the activities of HMG-CoA reductase,
glucose 6-phosphate dehydrogenase and malate dehydrogenase
were significantly reduced. Histological studies
showed less cholesterol deposits in the aorta of animals fed
with seed extract of C. paniculatus compared to the induced
hypercholesterolemic animals not given C. paniculatus
supplement.
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