Vladimir Poroikov » Публикация

Аннотация The objective of the present work was to synthesize and estimate mechanism of action, pharmacological activity and toxic or side effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives. Substituted chalcones were used as starting material. Chalcones comprising aryl moiety have been prepared by Claisen-Schmidt condensation of aromatic aldehydes with 4-Hydroxy acetophenone. All these pyrazoline derivativatives are characterised by IR, 1H-NMR and MS analysis. Prediction of Activity Spectra for Substances(PASS) is the computer program used in this work.Antifungal and antibacterial activities predicted by PASS was confirmed by experimental evaluation.