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Опубликовано 2011-02-09 Опубликовано на SciPeople2011-04-09 07:45:06 ЖурналJournal of Pharmacy Research

Synthesis and in silico biological activity evaluation of some 1,3,5-trisubstituted -2-pyrazolines
Prasad Y.R., Raja Sekhar K.K., Shankarananth V., Sireesha G., Swetha Harika K., Poroikov V. / Vladimir Poroikov
Journal of Pharmacy Research, 2011, 4 (2), 558-560.
Аннотация The objective of the present work was to synthesize and estimate mechanism of action, pharmacological activity and toxic or side effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives. Substituted chalcones were used as starting material. Chalcones comprising aryl moiety have been prepared by Claisen-Schmidt condensation of aromatic aldehydes with 4-Hydroxy acetophenone. All these pyrazoline derivativatives are characterised by IR, 1H-NMR and MS analysis. Prediction of Activity Spectra for Substances(PASS) is the computer program used in this work.Antifungal and antibacterial activities predicted by PASS was confirmed by experimental evaluation.


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