Опубликовано
2010-02-01
На SciPeople2011-06-01
ЖурналApplied Biochemistry and Microbiology
Effect of the Structure of the Brassinosteroid Side Chain on Monooxygenase Activity of Liver Microsomes
A. G. Sysa, P. A. Kiselev, V. N. Zhabinskii, and V. A. Khripach
/
Алексей Сыса
Аннотация
Possible pathways by which brassinosteroids affect the monooxygenase enzymatic system of
mammalian liver microsomes, which is involved in the transformation of a broad spectrum of xenobiotics,
were studied. The role of the structure of the side chain of brassinosteroids in the regulation of monooxygen
ase activity was studied using two natural compounds (24epibrassinolide and 28homobrassinolide) and two
synthetic analogues, (22S,23Sdihydroxy) stereoisomers. The results of this study show that brassinosteroids
can directly influence the functioning of the microsomal enzymatic system. It was found that the degree of
this influence depends on the side chain structure. This suggests the possibility of targeted modification of
natural compounds to ensure the desired physiological effects.
Публикация
Effect of the Structure of the Brassinosteroid Side Chain on Monooxygenase Activity of Liver Microsomes / A. G. Sysa [et al.]// Applied Biochemistry and Microbiology. – 2010. – Vol. 46. – No. 1. – Р. 23–27.
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