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Опубликовано 2011-12-25 Опубликовано на SciPeople2012-04-23 14:40:06 ЖурналSaratov Journal of Medical Scientific Research

Polymorphism of regulators of apoptosis and growth factors genes in chronic lymphatic leukemia

Bakirov В.A., Karimov D.O., Viktorova T.V. / Антон Киселев ^{контактное лицо}

Bakirov В.A., Karimov D.O., Viktorova T.V. Polymorphism of regulators of apoptosis and growth factors genes in chronic lymphatic leukemia // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 827-831

Аннотация The objective of the research is to study the role of polymorphic variants of Tumor Necrosis Factor (TNF) — a (TNFA), Bcl2-associated X protein (BAX) p53-Binding Protein (MDM2), vascular endothelial growth factor (VEGFA) and basic fibroblast growth factor (bFGF) genes in chronic lymphocytic leukemia (CLL). Methods: The comparative analysis of alleles and genotypes distributions in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out. Results: Analysis of the distribution frequency of genotypes and alleles of the genes studied has showed an increase in frequency of genotypes GG and allele G polymorphic locus-308G> A TNFA gene, GG and allele G of the polymorphic locus-248G>A BAX gene, allele G of the polymorphic locus 309T> G gene MDM2 and allele С polymorphic locus 773C>T bFGF gene in patients with CLL