«Саратовский научно-медицинский журнал» » Архив номеров » Volume 7, issue 4 » Публикация
Опубликовано
2011-12-25
Опубликовано на SciPeople2012-04-23 14:40:06
ЖурналSaratov Journal of Medical Scientific Research
Polymorphism of regulators of apoptosis and growth factors genes in chronic lymphatic leukemia
Bakirov В.A., Karimov D.O., Viktorova T.V. Polymorphism of regulators of apoptosis and growth factors genes in chronic lymphatic leukemia // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 827-831
Аннотация
The objective of the research is to study the role of polymorphic variants of Tumor Necrosis Factor (TNF) — a (TNFA), Bcl2-associated X protein (BAX) p53-Binding Protein (MDM2), vascular endothelial growth factor (VEGFA) and basic fibroblast growth factor (bFGF) genes in chronic lymphocytic leukemia (CLL). Methods: The comparative analysis of alleles and genotypes distributions in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out. Results: Analysis of the distribution frequency of genotypes and alleles of the genes studied has showed an increase in frequency of genotypes GG and allele G polymorphic locus-308G> A TNFA gene, GG and allele G of the polymorphic locus-248G>A BAX gene, allele G of the polymorphic locus 309T> G gene MDM2 and allele С polymorphic locus 773C>T bFGF gene in patients with CLL
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