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Опубликовано 2011-12-25 Опубликовано на SciPeople2012-04-23 14:40:06 ЖурналSaratov Journal of Medical Scientific Research

Urinary Cytokines Spectrum of Different Etiologic and Pathogenic Types at Children with Chronic Pyelonephritis

Merkodanova Yu.A., Utz I.A. / Антон Киселев ^{контактное лицо}

Merkodanova Yu.A., Utz I.A. Urinary Cytokines Spectrum of Different Etiologic and Pathogenic Types at Children with Chronic Pyelonephritis // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 901-904

Аннотация Objective. We investigated the diagnostic role of urinary IL-1b, IL-6 and IL-8 in children with different etiologic and pathogenic variants of chronic pyelonephritis. Material and methods. 132 patients (92 girls and 40 boys) aged 1-17 with chronic pyelonephritis were examined: 18 patients with primary pyelonephritis (I group); 114 with secondary pyelonephritis (II group); 30 patients without kidney disease completed control group. Results. Our data showed increasing level of all mediators of inflammation, especially in acute stage of pyelonephritis and with 10-years anamnesis. We suggested the role of IL-6 in nephrosclerosis. Conclusion. The content of urinary IL-1b, IL-6 reflects the level of kidney inflammation, and IL-8 — the degree of inflammation. We conclude that the level of urinary IL-8 could be a new indicator for nephrosclerosis