«Саратовский научно-медицинский журнал» » Архив номеров » Volume 7, issue 4 » Публикация
Опубликовано
2011-12-25
Опубликовано на SciPeople2012-04-23 14:40:06
ЖурналSaratov Journal of Medical Scientific Research
Morphological changes in urinary tract wall after direct electropulse effect: in vitro study
Gudkov А.V., Boshchenko V.S., Nedosekov V.V. Morphological changes in urinary tract wall after direct electropulse effect: in vitro study // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 937-941
Аннотация
The research goal is to study morphological changes after direct electropulse effect (DEPE) on the wall of urinary tract. Materials and methods: Materials of renal pelvis (25 fragments, n), ureter (n=33) and urinary bladder (n=20) from open surgeries were used. During the surgical intervention a few small fragments were resected to study the organ, immersed on a Petri-dish with solution of 0.9% NaCI. Mucosa was subjected to 1-20 single nanosecond electric impulses of intensity 0.8-1.0 J using probe of electropulse lithotriptor «Urolith-105M». The fragments were fixed in formalin, and then tissue sections were made. Results: Wall of renal pelvis was the most resistant to DEPE. Epithelial desquama-tion, basal disorganization, capillary dilatation and edema were observed within submucosal layer on application up to 10 impulses of intensity 1.0 J in the same point of mucosa. Walls of ureter and urinary bladder were less resistant to the DEPE, where just 5 impulses of intensity 1.0 J caused similar disorders, and 10 impulses of intensity 1.0 J caused damage to the entire thickness of the muscular layer up to adventitia. Conclusion: DEPE of urinary tract mucosa with a number of electric impulses from 1 to 20 with intensity of 0.8 to 1.0 J is a safe method. It causes morphological disorders within the muscular layer but it does not lead to wall perforation
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