«Саратовский научно-медицинский журнал» » Архив номеров » Volume 8, issue 1 » Публикация

Аннотация Aim: to evaluate arterial wall rigidity, clinical condition and prognosis in active and standard therapy of patients with chronic heart failure (CHF). Materials and methods. A total of 211 patients with CHF experienced Q-wave myocardial infarction was enrolled in the study. At admission to the hospital all patients were randomized into two groups. Patients of the first group (n=106) were managed actively after discharge from the hospital, patients of the second group (n=105) were managed conventionally after discharge from the hospital. Patients were observed for three years. Re-sults. Over three year-investigation actively managed patients demonstrated significant (p<0,05) decrease in systolic and diastolic blood pressure, heart rate, blood serum levels of total cholesterol, N-terminal cerebral natriuretic peptide, increase of 6-minute walk-test, left ventricle ejection fraction reduction and decrease in number hospitalization of patients with CHF as compared to those who were conventionally managed. At patients of II group pulse wave speed in aorta (PWVA) since the first year, an index of augmentation of brachial artery and systolic pressure in aorta in three years of supervision above (p<0,05) in comparison with patients of group I. Conclusion. One of deterioration factors of systolic functions of the left ventricle and the prognosis in patients with CHF of group of standard therapy was progressing of arterial wall rigidity pathology