«Саратовский научно-медицинский журнал» » Архив номеров » Volume 8, issue 2 » Публикация

Поделиться публикацией:
Опубликовать в блог:
Опубликовано 2012-06-25 Опубликовано на SciPeople2012-12-05 15:29:51 ЖурналSaratov Journal of Medical Scientific Research


Functional state of kidneys in patients with clinical manifestations of hypothyroidism
Orlova М.М., Rodionova T.I. Functional state of kidneys in patients with clinical manifestations of hypothyroidism // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 333-338
Аннотация The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ГА, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods: The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results: The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentra-tional kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokine MCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion: It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression
Ключевые слова публикации:
     

Комментарии

Вам необходимо зайти или зарегистрироваться для комментирования
Этот комментарий был удален
Этот комментарий был удален