«Саратовский научно-медицинский журнал» » Архив номеров » Volume 8, issue 2 » Публикация

The goal of the research was the comparative analysis of affective and cognitive disorders headache at women and men with dyscirculatory encephalopathy (DE), identify the connection of these disorders with the cerebral hemodynam-ics, neuroimaging of cinerea changes and BDNF in patients’ blood serum. 72 women (middle age 64,3±1,0) and 48 comparable in age and education men (middle age 65,0±1,2) with initiatory stages of dyscirculatory encephalopathy (DE) have been studied using comparative analysis of neuropsychological, sonographic and neuroimaging characteristics. The research revealed the predomination of cognitive impairment among men with (DE), especially attention, verbal coding and praxis disorders. Affective and insomnia disorders prevailed with women-patients. The results have shown possible links between low levels of brain-derived neurotrophic factor (BDNF) in blood plasma and the severity of depression and cognitive impairment at patients with (DE), especially at men. The received results may be important for individualization of therapeutic intervention.