Публикация

Поделиться публикацией:

Опубликовано 22 дек 2012 На SciPeople 22 дек 2012 Журнал Cheminė Technologija

Synthesis, computational and antimicrobial studies of new 1,4-naphthoquinone aminothiazole derivatives

Buchkevych I., Stasevych M., Chervetsova V., Musyanovych R., Novikov V., Poroikov V., Gloriozova T., Filimonov D., Zagoriy G., Ponomarenko M. / Vladimir Poroikov

22 дек 2012

Аннотация

The synthesis of new aminothiazole derivatives on the basis of substituted 1,4-naphthoquinones was carried out by the interaction of 2-R-3,6-dichloro-7-acylamino-1,4-naphthoquinones and potassium thiocyanate, 3,6-dichloro-2,7-diacylamino-1,4-naphthoquinone and dithiocyanate, of 2-R-3,6-dichloro-7-amino-1,4-naphthoquinones, 2-amino-7-nitro-3,6-dichloro-1,4-naphthoquinone and thiourea with the subsequent cyclization in aminothiazoles of 1,4-naphthoquinone. The physical and chemical properties of these compounds were determined, and the methods of their preparation are presented. The PASS computer program was used to predict the biological activity spectra of the new 1,4-naphthoquinone aminothiazole derivatives and to determine the most promising biological activities for experimental testing. Antibacterial and fungicidal activities were studied using the cultures of Staphylococcus aureus, Escherichia coli and Candida tenuis microorganisms. Some of the study compounds were found to have a moderate antibacterial and fungicidal activity, which in more than 90 % of cases coincided with the computational predictions. The analysis of the structure – antimicrobial activity relationships provides recommendations for the design of the new derivatives. Some other biological activities have been predicted by PASS for these compounds, including antiviral, antineoplastic, immunomodulating, acute neurological disease treatment, antiparkinsonian, etc., which help to identify areas for the further research. Thus, the 1,4-naphthoquinone aminothiazole derivatives have been shown to be a promising class for the preparation of novel pharmacological agents with different applications.