Алексей Шмонин » Публикация
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Опубликовано
2008-00-00
Опубликовано на SciPeople2013-07-25 16:33:16
ЖурналCardiovasc Hematol Disord Drug Targets
Reduction of myocardial ischemia-reperfusion injury with pre- and postconditioning: molecular mechanisms and therapeutic targets. Cardiovasc Hematol Disord Drug Targets
Cardiovasc Hematol Disord Drug Targets. 2008 Mar; 8(1): P.47-65.
Аннотация
Abstract: Reduction of infarct size as well as alleviation of other ischemia- and reperfusion-associated injuries are the
goals of primary importance in cardiology. One of the remedies is considered to be myocardial preconditioning (PreCon)
referred usually to as an increased myocardial tolerance to prolonged ischemia following brief ischemic or non-ischemic
challenge. In this review, PreCon stimuli tested to date are considered including a number of mildly noxious factors applied
either locally to the myocardium or systemically. Recently, one more mode of heart protection against reperfusion
injury termed postconditioning (PostCon) has been developed. On the basis of ample evidence published, along with our
findings, a detailed comparative analysis of PreCon and PostCon is presented, with special emphasis on the cellular, molecular,
and pharmacological aspects of the topic as well as clinical applications, both implemented and awaiting practical
approval.