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Опубликовано 2013-10-25 Опубликовано на SciPeople2013-11-16 08:19:44 ЖурналInternational Journal of PharmTech Research

Elevation of oxidative stress in the testes of rat by vinclozolin
B.Bhavanarayana, P.Sreenivasula Reddy / Bodicharla Narayana
Аннотация Vinclozolin is one of the environmental contaminants, that has been shown to induce reproductive abnormalities in male rats. The aim of this study was to explore the adverse effects of vinclozolin on testicular oxidative stress in rats. Adult (100 day old) Wistar rats were injected inperitoneally with 1, 5 and 10 mg/kg bw vinclozolin on days 1, 7, 14 and 21 and maintained up to 50 days. The animals were killed by cervical dislocation at the end of maintainance period. Testes were isolated, cleared from adhering tissue/fluid and used to analyze oxidative status. A significant increase in the levels of lipid peroxidation was observed in the testis of vinclozolin exposed rats when compared with control rats. Furthermore, a significant decrease in the activity levels of antioxidant enzymes such as, superoxide dismutase, catalase was observed in the testis of vinclozolin treated rats when compared to control rats. The results were indicated that exposure to vinclozolin induces oxidative stress in the testis by increasing lipid peroxidation and decreasing the activities of antioxidant enzymes in rats. Our findings are consistent with a major role for accumulated free radical damage in the disruption of spermatogenic process in vinclozolin exposed rats thereby affects reproduction.
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