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Опубликовано 2013-02-00 Опубликовано на SciPeople2014-01-09 22:40:17

Relation between integrins forced oscillation, degree of actin cytoskeleton polymerization and content of free Ca2+ of fibroblasts

Kot E.V., Kot Yu.G., Grytsenko M.A., Altukhova L.V., Persky Ye.E. / Екатерина Кот

Kot E.V., Kot Yu.G., Grytsenko M.A., Altukhova L.V., Persky Ye.E. Relation between integrins forced oscillation, degree of actin cytoskeleton polymerization and content of free Ca2+ of fibroblasts // European Researcher. – 2013. – Vol. 40. – № 2 – 1. – Р. 226 – 232.

Аннотация The impact of integrins oscillation on intracellular calcium in conditions of native actin microfilaments network and under depolymerization was studied on the model of α(2)β(1)-integrins forced cyclic fluctuations with the use of integrin-specific magnetic microparticles, that were exposed to magnetic field after being cell-attached. It proved that α(2)β(1)-integrins are involved in the response of fibroblasts to mechanical deformation, activating depot-dependent calcium efflux in cytoplasm. Cytoskeletal actin microfilaments are also involved in the response via these receptors, which integrity is essential for normal functioning of the depot-dependent mechanism of Ca2+ efflux in cytoplasm of deformable fibroblasts.