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Опубликовано 2001-03-00 Опубликовано на SciPeople2014-03-12 14:48:38 ЖурналJournal of Industrial Microbiology and Biotechnology

Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus.

Parshikov I.A., Freeman J.P., Lay J.O. Jr., Moody J.D., Williams A.J., Beger R.D., Sutherland J.B. / Игорь Паршиков

J. Ind. Microbiol. Biotechnol. 2001. V. 26. P.140-144.

Аннотация To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26% and 15% of the A 280, respectively) were identified by mass and 1H nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin. The biological formation of desethylene-N-acetylsarafloxacin has not been previously observed.