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Опубликовано
2014-03-24
Опубликовано на SciPeople2014-04-02 08:37:35
ЖурналVirus Research
Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins.
Virus Res. Volume 185, 24 June 2014, Pages 53–63 2014 Mar 24. pii: S0168-1702(14)00122-1. doi: 10.1016/j.virusres.2014.03.015
Аннотация
Influenza A virus is one of the major human pathogens. Despite numerous efforts
to produce absolutely effective anti-influenza drugs or vaccines, no such agent
has been developed yet. One of the main reasons for this complication is the high
mutation rate and the specific structure of influenza A viruses genome. For more
than 25 years since the first mapping of the viral genome, it was believed that
its 8 genome segments encode 10 proteins. However, the proteome of influenza A
viruses has turned out to be much more complex than previously thought. In 2001,
the first accessory protein, PB1-F2, translated from the alternative open reading
frame, was discovered. Subsequently, six more proteins, PB1-N40, PA-X, PA-N155,
PA-N182, M42, and NS3, have been found. It is important to pay close attention to
these novel proteins in order to evaluate their role in the pathogenesis of
influenza, especially in the case of outbreaks of human infections with new avian
viruses, such as H5N1 or H7N9. In this review we summarize the data on the
molecular mechanisms used by influenza A viruses to expand their proteome and on
the possible functions of the recently discovered viral proteins.