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Опубликовано 2013-12-25 Опубликовано на SciPeople2014-06-23 11:28:14 ЖурналSaratov Journal of Medical Scientific Research

ММР and RHOA gene expression in persoms exposed to ionizing radiation

Mikhailov V.F., Zasukhina G.D., Shishkina A.A., Shulenina L.V. / Антон Киселев ^{контактное лицо}

Mikhailov V.F., Zasukhina G.D., Shishkina A.A., Shulenina L.V. ММР and RHOA gene expression in persoms exposed to ionizing radiation // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 780-783

Аннотация The purpose of the study is to investigate the mechanisms of MMP-7, -13, TIMP-2 and RhoA genes expression in blood cells after ionizing radiation exposure. Material and methods.\Ne had examined blood samples from 27 healthy donors, 32 prostate cancer patients before and after radiotherapy, and 32 Chernobyl liquidators by qRT-PCR method. Result. Our results suggests that the expression of MMP-7, MMP-13 genes in prostate cancer patients with grade 2 (T2N0M0). Probably, these changes were associated with the tumor process development, but no with radiation therapy. RhoA level in blood of liquidators was decreased.