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Опубликовано 2011-02-01 Опубликовано на SciPeople2014-08-13 20:48:02 ЖурналMoscow University Biological Sciences Bulletin

Design of Mutant Variants of Horse Cytochrome C by Analysis of Informational Structure Method and Testing its Biological Activity
T. V. Ostroverkhova, R. V. Chertkova, A. N. Nekrasov, D. A. Dolgikh, M. P. Kirpichnikov / Алексей (alexei) Некрасов (nekrasov)
Moscow University Biological Sciences Bulletin, 2011, Vol. 66, No. 2, pp. 65–67.
Аннотация Informational structure of cytochrome c was investigated using the ANIS method (Analysis of Informational Structure Method). Mutant variants of cytochrome c gene were constructed on the basis of data from the ANIS method. The mutations carry substitutions reducing electrontransport activity of cytochrome c in the mitochondrial respiratory chain. These mutant genes were obtained and expressed in the bacterial system. The biological activity of the obtained cytochrome c mutant variants interacting with complexes III and IV of the respiratory chain in the system of rat liver mitoplasts.
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