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Опубликовано 2014-03-25 Опубликовано на SciPeople2014-08-31 23:42:46 ЖурналSaratov Journal of Medical Scientific Research


Efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle invasive urinary bladder cancer
Ponukalin A.N., Maslyakova G.N., Tsmokalyuk E.N. / Антон Киселев контактное лицо
Ponukalin A.N., Maslyakova G.N., Tsmokalyuk E.N. Efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle invasive urinary bladder cancer // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 124-128
Аннотация Objective: to carry out the comparative efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle-invasive urinary bladder cancer. Material and methods. Surgical material has included 80 patients with urinary bladder neoplasms. Clinical, histological, immunohistochemical and statistical methods of research has been used. Results. The immunohistochemical investigation has showed that only 4 markers from the 12 (Ki-67, рбЗ, p53 и EGFR) make possible to determine the stage of urinary bladder cancer and the disease prognosis. Conclusion. The proliferative activity of marker Ki-67 can be used as an auxiliary marker in the choice of volume of surgical treatment, which could predict an unfavorable outcome of disease in 81,2% of cases.
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