Russian Open Medical Journal » Архив номеров » Volume 1, issue 1 » Публикация

Аннотация The objective of the research is to study the role of polymorphic gene variants of Tumor Necrosis Factor-α (TNFA), Bcl-2-associated X protein (BAX), p53 Binding Protein (MDM2), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the development of chronic lymphocytic leukemia (CLL). Methods: The comparative analysis of allele and genotype frequency distribution in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out. Results: Analysis of distribution of genotype and allele frequencies of the genes under study has shown that patients with CLL were likely to demonstrate an increased frequency of GG-genotype and G-allele of polymorphic locus-308G>A of TNFA gene, GG-genotype and G-allele of the polymorphic locus-248G>A of BAX gene, G-allele of the polymorphic locus 309T> G of MDM2 gene and allele C of polymorphic locus 773C>T of bFGF gene.