Алексей (alexei) Некрасов (nekrasov) » Публикация
Поделиться публикацией:
Опубликовано
2014-10-01
Опубликовано на SciPeople2014-11-09 22:38:36
ЖурналRussian Journal of Numerical Analysis and Mathematical Modelling
The method for identification of hierarchical organization of protein sequences
Russian Journal of Numerical Analysis and Mathematical Modelling (2014) vol. 29(5), pp. 265–273
Аннотация
The paper describes a new method of Information Structure Analysis (ISAN) for protein
sequences. The method uses a new approximation for description of protein sequences, which allows
us to detect hierarchically organized elements (Information Structure Elements (ISEL)) in them. It
is shown that elements of the higher hierarchy level of information structure correspond to stable
elements in the spatial structure of globular proteins. Based on the ISAN method, we propose an approach
to design of the new sequences of recombinant proteins. The proposed approach was confirmed
experimentally in the case of obtaining functionally active recombinant proteins.
RJNAMM_2014.pdf
957,8 Kb