«Саратовский научно-медицинский журнал» » Архив номеров » Volume 10, issue 4 » Публикация

Аннотация Aim: to examine the therapeutic efficiency of melanin administered to mice after irradiation at lethal and sublethal doses. Material and methods: Survival and hematological states were studied on CD-1 mice receiving on acute or fractionated whole-body doses on X-rays or gamma-irradiation. Melanin soluble was given with water ad libitum from the first to the 30th-day after irradiation. Results. It was shown that melanin produced a significant therapeutic and protective-therapeutic action against acute radiation injury in the dose range 6,5-7,5 Gy (LD80-LD under our conditions). Cumulative survival melanin treated mice was increased to 14,4%, in control group — 1,9%. After fractionated injury (1 Gy daily, total dose 10 Gy) all mice which consumed melanin remained alive, versus 43,7% in control. Melanin decreased radiation-induced damage and stimulated the hematopoiesis recovery after sublethal exposure (5Gy). Conclusion. The results permit to regard melanin as a therapeutic agent for treatment of radiation injuries.