Дмитрий Гусаров » Публикация
Опубликовано
2009-00-00
Опубликовано на SciPeople2009-06-05 13:19:44
ЖурналRussian Journal of Biopharmaceuticals
Analytical determination of the B30-desthreonine-human insulin in insulin preparations
Russian Journal of Biopharmaceuticals. 2009. V.1. No.1. P.28-33.
Аннотация
The hydrolysis of recombinant preproinsulin yields the human insulin as a main product and also B30-desthreonine insulin as one of the by-products. Since physicochemical properties of human genetic insulin and B30-desthreonine insulin are similar its chromatographic behavior is also nearly the same. That is why it is complicated to determine analytically the percentage of B30-desthreonine insulin in insulin-containing solutions. In the given study the development of the analytical quantitation of B30-desthreonine insulin by means of HPLC was described.
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