Сергей (sergei) Остроумов (ostroumov) » Публикация

Аннотация Ostroumov S. A., and L. N. Vorobiev. Membrane potential and surface charge densities as possible generalized regulators of membrane protein activities. - Journal of Theoretical Biology 1978. Volume 75, Issue 3, 7 December 1978, Pages 289-297. Journal of Theoretical Biology. Volume 75, Issue 3, [7 December] 1978, Pages 289-297 doi:10.1016/0022-5193(78)90335-1. Copyright © 1978 Published by Elsevier Ltd. Membrane potential and surface charge densities as possible generalized regulators of membrane protein activities. S. A. Ostroumov [Corresponding Author, Contact Information, a, b, c], and L. N. Vorobiev. Affiliations: a Dept. of Bioenergetics, Belozersky Lab., Moscow State University, Moscow, U.S.S.R. (former address at the moment of publication); b M. M. Shemiakin Institute of Bioorganic Chemistry, Moscow 117312, U.S.S.R. (former address at the moment of publication); c At present one of the authors (S. O.) is at Laboratory of Physico-Chemistry of Biomembranes, Biological Faculty, M.V.Lomonosov Moscow State University, Moscow, Russian Federation. Received 28 November 1977; Revised 30 March 1978. Available online 15 December 2004. ABSTRACT: On the basis of experimental evidence accumulated in studies of coupling and other membranes a theoretical discussion of a “breathing” membrane structure dependent upon a changing transmembrane electrical (electrochemical) gradient is presented. In the case of certain membranes difference of electrical potentials across the membrane (Δψ) is considered as one of important driving forces for some membrane protein folding and/or the arrangement of subunits within some oligomeric proteins. Δψ changes may induce synchronous reversible energetically favourable transitions in the three-dimensional architecture of several spatially separated proteins of the biomembrane. A polyfunctional regulation of levels of activities of spatially separated membrane proteins may be achieved; in some cases alterations of Δψ and surface charge densities may fulfil function of a link in the chain of events triggering membrane-bound activities in response to external stimuli. Key issues: biomembranes, membrane potential,surface charge densities, regulators, membrane proteins, activities; http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4F1J81C-6V&_user=10&_coverDate=12%2F07%2F1978&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1279607346&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=369706b45f7fb8f7feaa41f2e1d22fb4;