«Саратовский научно-медицинский журнал» » Архив номеров » Volume 6, issue 1 » Публикация
Опубликовано
2010-03-25
Опубликовано на SciPeople2010-04-20 23:31:26
ЖурналSaratov Journal of Medical Scientific Research
Criteria of Clinical Diagnostics and Choice of Treatment Strategy in Children with Disoders of Sexual Development
N.V. Bolotova, D.A. Morozov, N.U. Raygorodskaya, D.A. Zharkov, M.M. Grigorjeva, E.N. Tsmokalyuk Criteria of Clinical Diagnostics and Choice of Treatment Strategy in Children with Disoders of Sexual Development // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 1, 2010, pp. 178-182
Аннотация
The number of patients with disorders of sexual development (DSD) has increased in 3.54 times during the last three years. The aim is to define the structure of intersexual disorders in children from Saratov, criteria of gender assignment and surgical approach. During the period of three years (from 2006 till 2008) 58 children with DSD aged 0 - 17 were examined. Assessment of external genitals, cytogenetic investigation, hormonal tests were performed. Imaging studies included ultrasonography, cystourethroscopy and laparoscopy with histological investigation. Considering the data DSD in children from Saratov compose sex chromosome DSD - 21,4 %, Gonadal dysgenesis - 26,2%, ovotesticular DSD - 2,3%, 46,ХХ testicular DSD - 2,3 %, complete androgen insensitivity syndrome - 4,7%. The criteria of gender assignment and surgical approach have been described in the article. The research concludes that the infants with intersexual genitels should be examined in special care centers by multispecialty team. It is nessesary to perform the karyotype test and ultrasonic study in newborns to detect the genetic and gonadal gender of the child
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