Dubey Dutta Kshatresh

PhD, Researcher    /    Индия, город не указан


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Biophysics Unit, Department of Physics, DDU Gorakhpur University
I am dynamic researcher interested in new and innovative research. Besides academic curriculum, I am interested in video gaming and music.

Сфера научных интересов


Stability of Trimeric DENV Envelope Protein at Low and Neutral pH: An Insight from MD Study

Kshatresh Dutta Dubey, Amit Kumar Chaubey and Rajendra Prasad Ojha
Change in pH plays crucial role in stability and function of dengue envelope (DENV) protein during conformational transition from dimeric pre-fusion state) to trimeric form (post-fusion state). In the present study we have performed various molecular dynamics (MD) simulations of trimeric DENV...

Conformational flexibility, binding energy, role of salt bridge and alanine-mutagenesis for c-Abl tyrosine kinase complex.

Kshatresh Dutta Dubey and Rajendra Prasad Ojha
Abl kinase plays a decisive role in the mechanism of the most fatal human pathogen chronic mylogenous leukemia (CML). Here, we have carried out a comprehensive study about the conformational flexibility, role of salt bridge and the protein- ligand interaction for this kinase with its well-known...

Role of pH on dimeric interactions for DENV envelope protein: An insight from molecular dynamics study

Kshatresh Dutta Dubey, Amit Kumar Chaubey, Rajendra Prasad Ojha
The entry of dengue viruses is mediated by pH triggering in the host cells. Here we have studied the DENV E protein stability and binding of its units at low and normal pH using MD and MM-PB/SA method for the first time. To investigate the role of pH in dissociation of dimeric protein, we have...