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The Paterson Institute for Cancer Research, University of Manchester 

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Postdoctoral Scientist -Stem Cell Biology

- Job Ref: PI/10/42
- 3 year fixed-term contract

A three year position is available in the laboratory of Dr Georges Lacaud to study the role of the transcription factor AML1/Runx1 in early haematopoietic development and how alterations of its function leads to leukaemogenesis. AML1/Runx1 is a frequent target of gene rearrangements and mutations in human Acute Myelogenous Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) and also a master regulator of haematopoietic stem cells development. The in vitro differentiation system based on mouse Embryonic Stem (ES) cells and in vivo approaches will be used. Selected references: Lancrin et al., (2009) Nature. Sroczynska et al.,(2009) Blood.

The successful applicant should have a PhD in cellular biology or molecular biology. A background in haematopoiesis, immunology, leukaemogenesis or developmental biology is desirable but not required.

Informal enquiries should be directed to Dr Georges Lacaud glacaud@picr.man.ac.uk

The Paterson Institute is a leading cancer centre of excellence core-funded by Cancer Research UK and is an Institute of The University of Manchester. Salary in the range of

<br /> Postdoctoral Scientist -Stem Cell Biology <br /><br />- Job Ref: PI/10/42<br />- 3 year fixed-term contract<br /><br />A three year position is available in the laboratory of Dr Georges Lacaud to study the role of the transcription factor AML1/Runx1 in early haematopoietic development and how alterations of its function leads to leukaemogenesis. AML1/Runx1 is a frequent target of gene rearrangements and mutations in human Acute Myelogenous Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) and also a master regulator of haematopoietic stem cells development. The in vitro differentiation system based on mouse Embryonic Stem (ES) cells and in vivo approaches will be used. Selected references: Lancrin et al., (2009) Nature. Sroczynska et al.,(2009) Blood.<br /><br />The successful applicant should have a PhD in cellular biology or molecular biology. A background in haematopoiesis, immunology, leukaemogenesis or developmental biology is desirable but not required.<br /><br />Informal enquiries should be directed to Dr Georges Lacaud glacaud@picr.man.ac.uk<br /><br />The Paterson Institute is a leading cancer centre of excellence core-funded by Cancer Research UK and is an Institute of The University of Manchester. Salary in the range of