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Опубликовано 2012-02-12 Опубликовано на SciPeople2012-04-01 00:25:32 ЖурналJournal of Physics: Conference Series

Morphological changes in the kidney, liver and spleen during prolonged administration of iron nanoparticles

N.A. Navolokin, G.N. Maslyakova, A.B. Bucharskya, X.M. Kong, V.V. Zuev, B.A. Medvedev, A.A. Ignatiev, T.V. Bochkaryeva / Никита Наволокин

N A Navolokin et al 2012 J. Phys.: Conf. Ser. 345 012043 doi:10.1088/1742-6596/345/1/012043

Аннотация We determined the cytotoxic effect of iron nanoparticles of 70 nm, with a single per oral administration in an experiment on white outbred mice. Morphological changes were evaluated in the internal organs. Thus, changes depend on the concentration of nanoparticles at long-term per oral exposure: identified violations of the structure of the liver, kidneys and spleen as venous plethora and degeneration of cells at 250 and 500 mkg / kg dose of nanoparticles are reversible, changes in the organs were pronounced with a dosage of 1000 mkg / kg.