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Опубликовано 2013-03-21 Опубликовано на SciPeople2013-03-22 09:16:18 ЖурналPrion

Amyloidogenic peptide homologous to fragment 129–148 of human myocilin

Vladimir V. Egorov, Natalia A. Grudinina, Dmitry V. Lebedev, Aram A. Shaldzhyan, Alexander V. Slita, Alexey K. Sirotkin, Andrey V. Vasin and Michael M. Shavlovsky / Владимир Егоров

Prion, Volume 7, Issue 3 May/June 2013 Pages 248 - 252 http://dx.doi.org/10.4161/pri.24239

Аннотация Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues. We showed that the peptide DQLETQTRELETAYSNLLRD corresponding to N-terminal Leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in myocilin aggregation is discussed.